ORL^O22 — General Laboratory Order Response
Application reply from the LIS to a lab order OML^O21. ORL answers on content (assays accepted or rejected), distinct from the technical ACK that answers on delivery.
Purpose
When the EHR sends an OML^O21 (General Laboratory Order), the LIS replies ORL^O22 after business validation: assay codes present in catalogue, consistent specimen, prescriber rights, fasting conditions. The ORL carries an MSA AA (accepted), AE (application error) or AR (rejected), and an updated ORC with the LIS-allocated filler order number.
Segment structure
Structure ORL_O22: MSH, MSA, [ERR], [PID, [PV1]], ORC, OBR, [NTE], [SPM].
| Segment | Role |
|---|---|
MSA | Message Acknowledgment — AA / AE / AR. |
ERR | Error — application error detail. |
ORC | Common Order — status (IP, CA, RP, UA), allocated LIS #. |
OBR | Observation Request — accepted or rejected assay. |
SPM | Specimen — confirmation of expected specimen. |
Real-world example — acceptance
LIS accepts a CBC requested by the EHR:
MSH|^~\&|LIS|LAB01|EHR|HOSP01|20260518161000||ORL^O22^ORL_O22|ORL22001|P|2.5.1|||AL|NE
MSA|AA|OML21999
PID|1||MR550321^^^HOSP^MR||TEISSIER^LUCAS^^^MR.||19920215|M
ORC|OK|ORD20260518777|LAB20260518017||IP|||20260518160000|||DR_CARRE^Carre^Aline
OBR|1|ORD20260518777|LAB20260518017|CBC^Complete Blood Count^L|||20260518155000||||||||SER||||LAB20260518017||||LAB||FError case — unknown assay code
MSH|^~\&|LIS|LAB01|EHR|HOSP01|20260518161000||ORL^O22^ORL_O22|ORL22002|P|2.5.1|||AL|NE
MSA|AE|OML21998|Unknown assay code
ERR|^^^207&Unknown assay code: 999XYZ&HL70357
ORC|UA|ORD20260518778|LAB20260518018||IP
OBR|1|ORD20260518778|LAB20260518018|999XYZ^Unknown code^LCommon errors
- MSA AA + ORC UA: inconsistency — if an assay is rejected, the MSA should be AE/AR.
- ERR without HL7 Table 0357: the EHR cannot react intelligently to the error code.
- Empty ORC-3 (Filler Order Number): the EHR loses traceability of the allocated LIS #.
- Late asynchronous reply: some EHR time out at 30 s default.